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Obregonia denegrii has a very small geographic range near Ciudad Victoria in the Valley of Jaumave, Tamaulipas, Mexico, There are no more than five subpopulations, all of them are found in one location. The population consists of less than 5,000 plants, and it continues to decrease due to collecting.
Obregonia is among the most famous of all cacti for is unique artichoke-shaped stem. It is the only representative of its monospecific genus and is related to Ariocarpus. It grows almost always as a solitary plant levelled with the ground, with the sunk and woolly apex. It is considered an intermediate form between Ariocarpus and Lophophora.
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